Alterations of Cardiac Enzymes Induced by Ketoprofen and the Potential Therapeutic Role of Ganoderma lucidum in Male Albino Rats

• Yasmeen Hamad

  Department of Zoology, Faculty of Science, Omar AL-Mukhtar University, El-Beyda, Libya.

  Author

• Faraj Jalboub

  Department of Physiology, Faculty of Veterinary Medicine & Agriculture Sciences, Zawia University, El- Zawia

  Author

• Salah Kamies

  Department of Physiology, Faculty of Veterinary Medicine, Omar AL-Mukhtar University, El-Beyda, Libya.

  Author

• Nura Al-Zail

  Department of Zoology, Faculty of Science, Omar AL-Mukhtar University, El-Beyda, Libya.

  Author

• Eda Alshailabi

  Department of Zoology, Faculty of Science, Omar AL-Mukhtar University, El-Beyda, Libya

  Author

• Marfoua Ali

  Department of Zoology, Faculty of Science, Omar AL-Mukhtar University, El-Beyda, Libya

  Author

Ketoprofen (KP) is a widely prescribed non-steroidal anti-inflammatory drug generally used to relieve pain and decrease inflammation. In contrast, Ganoderma lucidum, known as the Reishi mushroom, is valued as a medicinal fungus rich in bioactive complexes that contribute to its nutritional and therapeutic potential. This study explored the potential protective role of G. lucidum (GL) extract against KP-induced alterations in cardiac function. The assessment covered changes in cardiac enzyme activity in both serum and tissue, in addition to related cardiac indicators such as cortisol and calcium levels, along with lactate dehydrogenase and anti-cardiolipin IgG. 28 adult male rats were employed, and they were divided into four groups at random (n = 7 per group). No treatment was given to the control group. For four weeks, the GL group received oral G. lucidum extract at a dose of 300 mg/kg b. w./d. For two weeks, the KP group was given 50 mg/kg b. w./d. of KP orally. The combination group (KP+GL) received oral G. lucidum for four weeks in addition to KP at the same dose for two weeks. The results displayed that KP exposure caused significant elevations in serum and tissue cardiac enzymes, lactate dehydrogenase, and anti-cardiolipin IgG levels; at the same time, it caused a significant decrease in blood calcium levels. On the other side, G. lucidum supplementation in the combination group demonstrated significant improvements in these parameter levels. This study concluded that G. lucidum extract has therapeutic potential in mitigating KP-induced cardiac dysfunctions.

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