Parathyroid Hormone, Calcium, and Phosphorus Levels in Chronic Kidney Disease Patients: A Comprehensive Analysis

Abstract

This study examines the relationship between parathyroid hormone, calcium, and phosphorus levels in chronic kidney disease patients, focusing on the biochemical changes before and after dialysis. Data were collected from 38 patients across two dialysis centres, analyzing the correlation between these parameters and disease progression. The results indicated a higher prevalence of male patients in the middle-aged group (40-60 years), with comorbidities like hypertension (70%) and diabetes (45%) contributing to the exacerbation of kidney damage. Analysis showed slight improvements in calcium and phosphorus levels after three months of dialysis, with phosphorus decreasing by 10% and calcium increasing by 5%. However, some imbalances persisted, reflecting ongoing challenges in managing mineral disturbances. Parathyroid hormone levels decreased modestly by 15% but remained a critical marker of disease progression due to their link with secondary hyperparathyroidism. This study underscores the need for an integrated approach to managing chronic kidney disease, including continuous monitoring, dietary adjustments, and hormonal regulation, to improve patient outcomes and reduce complications.